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MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors

We analyzed MET protein and copy number in NSCLC with or without EGFR mutations untreated with EGFR tyrosine kinase inhibitors (TKIs). MET copy number was examined in 28 NSCLC and 4 human bronchial epithelial cell lines (HBEC) and 100 primary tumors using quantitative real-time PCR. Positive results...

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書誌詳細
主要な著者: Kubo, Takafumi, Yamamoto, Hiromasa, Lockwood, William W., Valencia, Ilse, Soh, Junichi, Peyton, Michael, Jida, Masaru, Otani, Hiroki, Fujii, Tetsuya, Ouchida, Mamoru, Takigawa, Nagio, Kiura, Katsuyuki, Shimizu, Kenji, Date, Hiroshi, Minna, John D., Varella-Garcia, Marileila, Lam, Wan L., Gazdar, Adi F., Toyooka, Shinichi
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767331/
https://ncbi.nlm.nih.gov/pubmed/19117057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24150
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