MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors

We analyzed MET protein and copy number in NSCLC with or without EGFR mutations untreated with EGFR tyrosine kinase inhibitors (TKIs). MET copy number was examined in 28 NSCLC and 4 human bronchial epithelial cell lines (HBEC) and 100 primary tumors using quantitative real-time PCR. Positive results...

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Detalhes bibliográficos
Main Authors: Kubo, Takafumi, Yamamoto, Hiromasa, Lockwood, William W., Valencia, Ilse, Soh, Junichi, Peyton, Michael, Jida, Masaru, Otani, Hiroki, Fujii, Tetsuya, Ouchida, Mamoru, Takigawa, Nagio, Kiura, Katsuyuki, Shimizu, Kenji, Date, Hiroshi, Minna, John D., Varella-Garcia, Marileila, Lam, Wan L., Gazdar, Adi F., Toyooka, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767331/
https://ncbi.nlm.nih.gov/pubmed/19117057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24150
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