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Demyelinated Axons And Motor Function Are Protected by Genetic Deletion of Perforin in a Mouse Model of Multiple Sclerosis

Axon injury is a major determinant of the loss of neurologic function in patients with multiple sclerosis (MS). It is unclear, however, whether damage to axons is an obligatory consequence of demyelination or whether it is an independent process that occurs in the permissive environment of demyelina...

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Autors principals: Deb, Chandra, LaFrance-Corey, Reghann G., Zoecklein, Laurie, Papke, Louisa, Rodriguez, Moses, Howe, Charles L.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767116/
https://ncbi.nlm.nih.gov/pubmed/19680139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e3181b5417e
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