Co-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: a highly active combination against human Mantle Cell Lymphoma (MCL) cells

Heat shock protein (hsp) 90 inhibitors promote proteasomal degradation of pro-growth and pro-survival hsp90 client proteins, including CDK4, c-RAF and AKT, and induce apoptosis of human lymphoma cells. The pan-histone deacetylase inhibitor vorinostat has also been shown to induce growth arrest and a...

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Autors principals: Rao, Rekha, Lee, Pearl, Fiskus, Warren, Yang, Yonghua, Joshi, Rajeshree, Wang, Yongchao, Buckley, Kate, Balusu, Ramesh, Chen, Jianguang, Koul, Sanjay, Joshi, Atul, Upadhyay, Sunil, Tao, Jianguo, Sotomayor, Eduardo, Bhalla, Kapil N.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766923/
https://ncbi.nlm.nih.gov/pubmed/19440035
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