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In Vitro Metabolism of 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin in Human Liver Microsomes

The objective of this study was to investigate the oxidative metabolism pathways of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), a geldanamycin (GA) derivative and 90-kDa heat shock protein inhibitor. In vitro metabolic profiles of 17-DMAG were examined by using pooled human live...

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Bibliographic Details
Main Authors: Zheng, Nan, Zou, Peng, Wang, Shaomeng, Sun, Duxin
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063720/
https://ncbi.nlm.nih.gov/pubmed/21177985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.036418
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