Radioprotective effects of oral 17-dimethylaminoethylamino-17-demethoxygeldanamycin in mice: bone marrow and small intestine

BACKGROUND: Our previous research demonstrated that one subcutaneous injection of 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) 24 hours (h) before irradiation (8.75 Gy) increased mouse survival by 75%. However, the protective mechanism of 17-DMAG is currently unknown. The present st...

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Библиографические подробности
Главные авторы: Lu, Xinyue, Nurmemet, Dilber, Bolduc, David L, Elliott, Thomas B, Kiang, Juliann G
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2013
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852109/
https://ncbi.nlm.nih.gov/pubmed/24499553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3701-3-36
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