Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: Inhibition by NSAIDs

AIMS: To characterize: i) the kinetics of aldosterone (ALDO) 18β-glucuronidation using human liver and human kidney microsomes and identify the human UGT enzyme(s) responsible for ALDO 18β-glucuronidation and ii) the inhibition of ALDO 18β-glucuronidation by non-selective NSAIDs. METHODS: Using HPLC...

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Dettagli Bibliografici
Autori principali: Knights, Kathleen M, Winner, Leanne K, Elliot, David J, Bowalgaha, Kushari, Miners, John O
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2009
Soggetti:
Drug Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766480/
https://ncbi.nlm.nih.gov/pubmed/19740398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03469.x
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