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Abrogation of Mitogen-Activated Protein Kinase and Akt Signaling by Vandetanib Synergistically Potentiates Histone Deacetylase Inhibitor-Induced Apoptosis in Human Glioma Cells
Vandetanib is a multitargeted tyrosine kinase inhibitor. Our initial studies demonstrated that this agent blocks vascular endothelial growth factor receptor, epidermal growth factor receptor, and platelet-derived growth factor receptor phosphorylation and mitogen-activated protein kinase (MAPK)-medi...
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Autori principali: | , , , |
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Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
The American Society for Pharmacology and Experimental Therapeutics
2009
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2766222/ https://ncbi.nlm.nih.gov/pubmed/19622715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.155705 |
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