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Abrogation of Mitogen-Activated Protein Kinase and Akt Signaling by Vandetanib Synergistically Potentiates Histone Deacetylase Inhibitor-Induced Apoptosis in Human Glioma Cells

Vandetanib is a multitargeted tyrosine kinase inhibitor. Our initial studies demonstrated that this agent blocks vascular endothelial growth factor receptor, epidermal growth factor receptor, and platelet-derived growth factor receptor phosphorylation and mitogen-activated protein kinase (MAPK)-medi...

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Main Authors: Jane, Esther P., Premkumar, Daniel R., Addo-Yobo, Steven O., Pollack, Ian F.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766222/
https://ncbi.nlm.nih.gov/pubmed/19622715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.155705
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