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Survivin Inhibitor YM-155 Sensitizes Tumor Necrosis Factor– Related Apoptosis-Inducing Ligand-Resistant Glioma Cells to Apoptosis through Mcl-1 Downregulation and by Engaging the Mitochondrial Death Pathway

Induction of apoptosis by the death ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising antitumor therapy. However, not all tumor cells are sensitive to TRAIL, highlighting the need for strategies to overcome TRAIL resistance. Inhibitor of apoptosis family member su...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Premkumar, Daniel R., Jane, Esther P., Foster, Kimberly A., Pollack, Ian F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716309/
https://ncbi.nlm.nih.gov/pubmed/23740602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.204743
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