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Experimental determination of the evolvability of a transcription factor

Sequence-specific binding of a transcription factor to DNA is the central event in any transcriptional regulatory network. However, relatively little is known about the evolutionary plasticity of transcription factors. For example, the exact functional consequence of an amino acid substitution on th...

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Bibliografiske detaljer
Main Authors: Maerkl, Sebastian J., Quake, Stephen R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765923/
https://ncbi.nlm.nih.gov/pubmed/19841254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907688106
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