Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition

Non-small cell lung cancers with activating mutations in the epidermal growth factor receptor (EGFR) are highly responsive to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. Such cancers are “addicted” to EGFR, and treatment with a TKI invariably leads to down-regulation of...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Faber, Anthony C., Li, Danan, Song, YoungChul, Liang, Mei-Chih, Yeap, Beow Y., Bronson, Roderick T., Lifshits, Eugene, Chen, Zhao, Maira, Sauveur-Michel, García-Echeverría, Carlos, Wong, Kwok-Kin, Engelman, Jeffrey A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2009
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765921/
https://ncbi.nlm.nih.gov/pubmed/19850869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905056106
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