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Opposing effects of TGF-β and IL-15 control the number of short-lived effector CD8(+) T cells

An effective immune response against infectious agents involves massive expansion of CD8(+) T cells. Once the infection is cleared, the majority of these effector cells die through unknown mechanisms, leaving behind only memory precursor cells. How is expansion controlled to maximize pathogen cleara...

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Bibliografiske detaljer
Main Authors: Sanjabi, Shomyseh, Mosaheb, Munir M., Flavell, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765785/
https://ncbi.nlm.nih.gov/pubmed/19604492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.04.020
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