Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways

BACKGROUND/AIMS: We have previously shown that phagocytosis of apoptotic bodies (AB) by hepatic stellate cells (HSC) is profibrogenic. As HSC survival is central to the progression of liver fibrosis, our goal was to investigate if phagocytosis induces HSC survival. METHODS: Apoptosis of phagocytosin...

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Hauptverfasser: Jiang, Joy X., Mikami, Kenichiro, Venugopal, Senthil, Li, Yong, Török, Natalie J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765371/
https://ncbi.nlm.nih.gov/pubmed/19457567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2009.03.024
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