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Chromatographic benefits of elevated temperature for the proteomic analysis of membrane proteins

Integral membrane proteins (IMPs) perform crucial cellular functions and are the primary targets for most pharmaceutical agents. However, the hydrophobic nature of their membrane-embedded domains and their intimate association with lipids makes them difficult to handle. Multiple proteomics platforms...

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Autori principali: Blackler, Adele R., Speers, Anna E., Wu, Christine C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765112/
https://ncbi.nlm.nih.gov/pubmed/18780350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.200800210
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