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Phosphonate Analogues of Cyclopropavir Phosphates and Their E-isomers. Synthesis and Antiviral Activity

Z- and E-phosphonate analogues 12 and 13 derived from cyclopropavir and the corresponding cyclic phosphonates 14 and 15 were synthesized and their antiviral activity was investigated. The 2,2-bis(hydroxymethylmethylenecyclopropane acetate (17) was transformed to tetrahydropyranyl acetate 18. Deacety...

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Autors principals: Mhaske, Santosh B., Ksebati, Bashar, Prichard, Mark N., Drach, John C., Zemlicka, Jiri
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765055/
https://ncbi.nlm.nih.gov/pubmed/19410465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.04.020
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