Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity

Cytosolic proteolysis is carried out predominantly by the proteasome. We show that a large oligopeptidase, tripeptidylpeptidase II (TPPII), can compensate for compromised proteasome activity. Overexpression of TPPII is sufficient to prevent accumulation of polyubiquitinated proteins and allows survi...

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Xehetasun bibliografikoak
Egile Nagusiak: Wang, Evelyn W., Kessler, Benedikt M., Borodovsky, Anna, Cravatt, Benjamin F., Bogyo, Matthew, Ploegh, Hidde L., Glas, Rickard
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The National Academy of Sciences 2000
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC27648/
https://ncbi.nlm.nih.gov/pubmed/10954757
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