Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity

Cytosolic proteolysis is carried out predominantly by the proteasome. We show that a large oligopeptidase, tripeptidylpeptidase II (TPPII), can compensate for compromised proteasome activity. Overexpression of TPPII is sufficient to prevent accumulation of polyubiquitinated proteins and allows survi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wang, Evelyn W., Kessler, Benedikt M., Borodovsky, Anna, Cravatt, Benjamin F., Bogyo, Matthew, Ploegh, Hidde L., Glas, Rickard
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27648/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10954757/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.180328897
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