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Ionization of Zwitterionic Amine Substrates Bound to Monomeric Sarcosine Oxidase
Monomeric sarcosine oxidase (MSOX) binds the L-proline zwitterion (pK(a) = 10.6). The reactive substrate anion is generated by ionization of the ES complex (pK(a) = 8.0). Tyr317 was mutated to Phe to determine whether this step might involve proton transfer to an active site base. The mutation does...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2764489/ https://ncbi.nlm.nih.gov/pubmed/16363800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi051898d |
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