Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2Rγ(null) Mice Engrafted with Human Erythrocytes

Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD-scid IL2Rγ(null) mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD-scid β2microglobulin(null)...

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Main Authors: Jiménez-Díaz, María Belén, Mulet, Teresa, Viera, Sara, Gómez, Vanessa, Garuti, Helen, Ibáñez, Javier, Alvarez-Doval, Angela, Shultz, Leonard D., Martínez, Antonio, Gargallo-Viola, Domingo, Angulo-Barturen, Iñigo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764183/
https://ncbi.nlm.nih.gov/pubmed/19596869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00519-09
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