Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rγ(null) (NSG) mice

Delayed engraftment remains a major hurdle following cord blood (CB) transplantation. It may be due, at least in part, to low fucosylation of cell surface molecules important for homing to the BM microenvironment. Since fucosylation of specific cell surface ligands is required before effective inter...

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Autori principali: Robinson, Simon N., Simmons, Paul J., Thomas, Michael W., Brouard, Nathalie, Javni, Jeannie A., Trilok, Suprita, Shim, Jae-Seung, Yang, Hong, Steiner, David, Decker, William K., Xing, Dongxia, Shultz, Leonard D., Savoldo, Barbara, Dotti, Gianpietro, Bollard, Catherine M., Miller, Leonard, Champlin, Richard E., Shpall, Elizabeth J., Zweidler, Patrick A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352960/
https://ncbi.nlm.nih.gov/pubmed/22306295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2012.01.015
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