Mechanism of Cis-Inhibition of PolyQ Fibrillation by PolyP: PPII Oligomers and the Hydrophobic Effect

PolyQ peptides teeter between polyproline II (PPII) and β-sheet conformations. In tandem polyQ-polyP peptides, the polyP segment tips the balance toward PPII, increasing the threshold number of Gln residues needed for fibrillation. To investigate the mechanism of cis-inhibition by flanking polyP seg...

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Hlavní autoři: Darnell, Gregory D., Derryberry, JohnMark, Kurutz, Josh W., Meredith, Stephen C.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2009
Témata:
Protein
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764074/
https://ncbi.nlm.nih.gov/pubmed/19843462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.07.062
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