Amyloid-Like Fibril Formation by PolyQ Proteins: A Critical Balance between the PolyQ Length and the Constraints Imposed by the Host Protein

Nine neurodegenerative disorders, called polyglutamine (polyQ) diseases, are characterized by the formation of intranuclear amyloid-like aggregates by nine proteins containing a polyQ tract above a threshold length. These insoluble aggregates and/or some of their soluble precursors are thought to pl...

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Detalhes bibliográficos
Main Authors: Scarafone, Natacha, Pain, Coralie, Fratamico, Anthony, Gaspard, Gilles, Yilmaz, Nursel, Filée, Patrice, Galleni, Moreno, Matagne, André, Dumoulin, Mireille
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305072/
https://ncbi.nlm.nih.gov/pubmed/22438863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031253
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