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Detecting Soluble PolyQ Oligomers and Investigating Their Impact on Living Cells Using Split-GFP
Aberrant expansion of the number of polyglutamine (polyQ) repeats in mutant proteins is the hallmark of various diseases. These pathologies include Huntington’s disease (HD), a neurological disorder caused by expanded polyQ stretch within the huntingtin (Htt) protein. The expansions increase the pro...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4112564/ https://ncbi.nlm.nih.gov/pubmed/23719920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-62703-438-8_17 |
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