Factor Xa Binding to Phosphatidylserine-Containing Membranes Produces an Inactive Membrane-Bound Dimer

Factor Xa (FXa) has a prominent role in amplifying both inflammation and the coagulation cascade. In the coagulation cascade, its main role is catalyzing the proteolytic activation of prothrombin to thrombin. Efficient proteolysis is well known to require phosphatidylserine (PS)-containing membranes...

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Detalles Bibliográficos
Main Authors: Koklic, Tilen, Majumder, Rinku, Weinreb, Gabriel E., Lentz, Barry R.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2009
Assuntos:
Membrane
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764068/
https://ncbi.nlm.nih.gov/pubmed/19843455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.07.043
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