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Phosphatidylserine-induced Factor Xa Dimerization and Binding to Factor Va Are Competing Processes in Solution

A soluble, short chain phosphatidylserine, 1,2-dicaproyl-sn-glycero-3-phospho-L-serine (C6PS), binds to discrete sites on FXa, FVa, and prothrombin to alter their conformations, to promote FXa dimerization (K(d) ~ 14 nM), and to enhance both the catalytic activity of FXa and the cofactor activity of...

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Detalhes bibliográficos
Main Authors: Majumder, Rinku, Koklic, Tilen, Rezaie, Alireza R., Lentz, Barry R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544317/
https://ncbi.nlm.nih.gov/pubmed/23214401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301239z
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