Mechanistic Studies on the Effects of Nicotinamide on Megakaryocytic Polyploidization and the roles of NAD(+) levels and SIRT inhibition

OBJECTIVE: Megakaryocytic cells (Mks) undergo endomitosis and become polyploid. Mk ploidy correlates with platelet production. We previously showed that nicotinamide (NIC) greatly increases Mk ploidy in cultures of human mobilized peripheral blood (mPB) CD34(+) cells. This study aims to examine the...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Giammona, Lisa M., Panuganti, Swapna, Kemper, Jan M., Apostolidis, Pani A., Lindsey, Stephan, Papoutsakis, Eleftherios T., Miller, William M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763937/
https://ncbi.nlm.nih.gov/pubmed/19715739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2009.08.004
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados