Mechanistic Studies on the Effects of Nicotinamide on Megakaryocytic Polyploidization and the roles of NAD(+) levels and SIRT inhibition

OBJECTIVE: Megakaryocytic cells (Mks) undergo endomitosis and become polyploid. Mk ploidy correlates with platelet production. We previously showed that nicotinamide (NIC) greatly increases Mk ploidy in cultures of human mobilized peripheral blood (mPB) CD34(+) cells. This study aims to examine the...

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Главные авторы: Giammona, Lisa M., Panuganti, Swapna, Kemper, Jan M., Apostolidis, Pani A., Lindsey, Stephan, Papoutsakis, Eleftherios T., Miller, William M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763937/
https://ncbi.nlm.nih.gov/pubmed/19715739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2009.08.004
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