Mechanistic Studies on the Effects of Nicotinamide on Megakaryocytic Polyploidization and the roles of NAD(+) levels and SIRT inhibition

OBJECTIVE: Megakaryocytic cells (Mks) undergo endomitosis and become polyploid. Mk ploidy correlates with platelet production. We previously showed that nicotinamide (NIC) greatly increases Mk ploidy in cultures of human mobilized peripheral blood (mPB) CD34(+) cells. This study aims to examine the...

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Detaylı Bibliyografya
Asıl Yazarlar: Giammona, Lisa M., Panuganti, Swapna, Kemper, Jan M., Apostolidis, Pani A., Lindsey, Stephan, Papoutsakis, Eleftherios T., Miller, William M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763937/
https://ncbi.nlm.nih.gov/pubmed/19715739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2009.08.004
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