Increased ectonucleotidase expression and activity in Treg of patients with head and neck cancer

PURPOSE: Regulatory T cells (Treg) frequency/activity are increased in cancer patients and play a major in tumor escape. While disease progression is favored by the presence of Treg, mechanisms used by Treg to suppress anti-tumor immunity are unknown. The ectonucleotidases CD39 and CD73 are expresse...

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Huvudupphovsmän: Mandapathil, Magis, Szczepanski, Miroslaw J., Szajnik, Marta, Ren, Jin, Lenzner, Diana E., Jackson, Edwin K., Gorelik, Elieser, Lang, Stephan, Johnson, Jonas T., Whiteside, Theresa L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763335/
https://ncbi.nlm.nih.gov/pubmed/19825957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1143
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