Generation and Accumulation of Immunosuppressive Adenosine by Human CD4(+)CD25(high)FOXP3(+) Regulatory T Cells

Naturally occurring regulatory T cells (nTreg) are crucial for maintaining tolerance to self and thus preventing autoimmune diseases and allograft rejections. In cancer, Treg down-regulate antitumor responses by several distinct mechanisms. This study analyzes the role the adenosinergic pathway play...

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Detalhes bibliográficos
Main Authors: Mandapathil, Magis, Hilldorfer, Benedict, Szczepanski, Miroslaw J., Czystowska, Malgorzata, Szajnik, Marta, Ren, Jin, Lang, Stephan, Jackson, Edwin K., Gorelik, Elieser, Whiteside, Theresa L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844167/
https://ncbi.nlm.nih.gov/pubmed/19858205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047423
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