Adenosine and Prostaglandin E(2) Cooperate in the Suppression of Immune Responses Mediated by Adaptive Regulatory T Cells

Adaptive regulatory T cells (Tr1) are induced in the periphery upon encountering cognate antigens. In cancer, their frequency is increased; however, Tr1-mediated suppression mechanisms are not yet defined. Here, we evaluate the simultaneous involvement of ectonucleotidases (CD39/CD73) and cyclooxyge...

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Detalhes bibliográficos
Main Authors: Mandapathil, Magis, Szczepanski, Miroslaw J., Szajnik, Marta, Ren, Jin, Jackson, Edwin K., Johnson, Jonas T., Gorelik, Elieser, Lang, Stephan, Whiteside, Theresa L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934624/
https://ncbi.nlm.nih.gov/pubmed/20558731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.127100
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