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Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent upon activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex

Alterations in chromatin play an important role in oncogenic transformation although the underlying mechanisms are often poorly understood. The SWI/SNF complex contributes to epigenetic regulation by utilizing the energy of ATP hydrolysis to remodel chromatin and thus regulate transcription of targe...

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Autors principals: Wang, Xi, Sansam, Courtney G., Thom, Christopher S., Metzger, Daniel, Evans, Julia A., Nguyen, Phuong T. L., Roberts, Charles W. M.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763035/
https://ncbi.nlm.nih.gov/pubmed/19789351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0733
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