Xist RNA antagonizes the SWI/SNF chromatin remodeler BRG1 on the inactive X chromosome

The noncoding RNA Xist recruits silencing factors to the inactive X chromosome (Xi) and facilitates re-organization of Xi structure. Here, we examine the mouse epigenomic landscape of Xi and assess how Xist alters chromatin accessibility. Interestingly, Xist deletion triggers a gain of accessibility...

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發表在:Nat Struct Mol Biol
Main Authors: Jégu, Teddy, Blum, Roy, Cochrane, Jesse C., Yang, Lin, Wang, Chen-Yu, Gilles, Maud-Emmanuelle, Colognori, David, Szanto, Attila, Marr, Sharon K., Kingston, Robert E., Lee, Jeannie T.
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421574/
https://ncbi.nlm.nih.gov/pubmed/30664740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0176-8
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