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Loss of the SWI/SNF ATPase subunits BRM and BRG1 drives lung cancer development

Inactivation of Brg1 and Brm accelerated lung tumor development, shortened tumor latency, and caused a loss of differentiation. Tumors with Brg1 and/or Brm loss recapitulated the evolution of human lung cancer as observed by the development of local tumor invasion as well as distal tumor metastasis,...

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發表在:Oncoscience
Main Authors: Marquez-Vilendrer, Stefanie B., Rai, Sudhir K., Gramling, Sarah JB, Lu, Li, Reisman, David N.
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5235921/
https://ncbi.nlm.nih.gov/pubmed/28105457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncoscience.323
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