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Xist deletional analysis reveals a co-dependency between Xist RNA and Polycomb complexes for spreading along the inactive X
During X-inactivation, Xist RNA spreads along an entire chromosome to establish silencing. However, the mechanism and functional RNA elements involved in spreading remain undefined. By performing a comprehensive endogenous Xist deletion screen, we identify Repeat B as crucial for spreading Xist and...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6469964/ https://ncbi.nlm.nih.gov/pubmed/30827740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.015 |
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