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Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent upon activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex
Alterations in chromatin play an important role in oncogenic transformation although the underlying mechanisms are often poorly understood. The SWI/SNF complex contributes to epigenetic regulation by utilizing the energy of ATP hydrolysis to remodel chromatin and thus regulate transcription of targe...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2763035/ https://ncbi.nlm.nih.gov/pubmed/19789351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0733 |
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