Inhibitor Binding of Group IVA Phospholipase A(2) Probed by Molecular Dynamics and Deuterium Exchange Mass Spectrometry

An analysis of Group IVA (GIVA) phospholipase A(2) (PLA(2)) inhibitor binding was conducted using a combination of deuterium exchange mass spectrometry (DXMS) and molecular dynamics (MD). Models of the GIVA PLA(2) inhibitors pyrrophenone and the 2-oxoamide AX007 docked into the protein were designed...

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Detalhes bibliográficos
Main Authors: Burke, John E., Babakhani, Arneh, Gorfe, Alemayehu A., Kokotos, George, Li, Sheng, Woods, Virgil L., McCammon, J. Andrew, Dennis, Edward A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762749/
https://ncbi.nlm.nih.gov/pubmed/19459633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja900098y
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