2-Arylamino-4-Amino-5-Aroylthiazoles. “One-Pot” Synthesis and Biological Evaluation of a New Class of Inhibitors of Tubulin Polymerization

The essential role of microtubules in mitosis makes them a major target of compounds useful for cancer therapy. In our search for potent antitumor agents, a novel series of 2-anilino-4-amino-5-aroylthiazoles was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymeri...

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Detalhes bibliográficos
Main Authors: Romagnoli, Romeo, Baraldi, Pier Giovanni, Carrion, Maria Dora, Cruz-Lopez, Olga, Cara, Carlota Lopez, Basso, Giuseppe, Viola, Giampietro, Khedr, Mohammed, Balzarini, Jan, Mahboobi, Siavosh, Sellmer, Andreas, Brancale, Andrea, Hamel, Ernest
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762271/
https://ncbi.nlm.nih.gov/pubmed/19663386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9001692
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