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Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide

AIMS: Our objective was to investigate whether pro-oxidant properties of ascorbic acid (AA) and tetrahydrobiopterin (BH(4)) modulate endothelium-dependent, electrotonically mediated arterial relaxation. METHODS AND RESULTS: In studies with rabbit iliac artery (RIA) rings, NO-independent, endothelium...

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Detalhes bibliográficos
Main Authors: Garry, Ambroise, Edwards, David H., Fallis, Ian F., Jenkins, Robert L., Griffith, Tudor M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761203/
https://ncbi.nlm.nih.gov/pubmed/19592567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvp235
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