Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

Ascorbate (ascorbic acid, vitamin C), in pharmacologic concentrations easily achieved in humans by i.v. administration, selectively kills some cancer cells but not normal cells. We proposed that pharmacologic ascorbate is a prodrug for preferential steady-state formation of ascorbate radical (Asc(•−...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chen, Qi, Espey, Michael Graham, Sun, Andrew Y., Lee, Je-Hyuk, Krishna, Murali C., Shacter, Emily, Choyke, Peter L., Pooput, Chaya, Kirk, Kenneth L., Buettner, Garry R., Levine, Mark
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2007
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885574/
https://ncbi.nlm.nih.gov/pubmed/17502596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702854104
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg