Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

Ascorbic acid is an essential nutrient commonly regarded as an antioxidant. In this study, we showed that ascorbate at pharmacologic concentrations was a prooxidant, generating hydrogen-peroxide-dependent cytotoxicity toward a variety of cancer cells in vitro without adversely affecting normal cells...

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Bibliographic Details
Main Authors: Chen, Qi, Espey, Michael Graham, Sun, Andrew Y., Pooput, Chaya, Kirk, Kenneth L., Krishna, Murali C., Khosh, Deena Beneda, Drisko, Jeanne, Levine, Mark
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516281/
https://ncbi.nlm.nih.gov/pubmed/18678913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804226105
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