Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

Ascorbic acid is an essential nutrient commonly regarded as an antioxidant. In this study, we showed that ascorbate at pharmacologic concentrations was a prooxidant, generating hydrogen-peroxide-dependent cytotoxicity toward a variety of cancer cells in vitro without adversely affecting normal cells...

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Detaylı Bibliyografya
Asıl Yazarlar: Chen, Qi, Espey, Michael Graham, Sun, Andrew Y., Pooput, Chaya, Kirk, Kenneth L., Krishna, Murali C., Khosh, Deena Beneda, Drisko, Jeanne, Levine, Mark
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516281/
https://ncbi.nlm.nih.gov/pubmed/18678913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804226105
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