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Structural basis of Toll-Like Receptor 3 Signaling with double-stranded RNA
Toll-like receptor 3 (TLR3) recognizes dsRNA, a molecular signature of most viruses, and triggers inflammatory responses that prevent viral spread. TLR3 ectodomains (ECD) dimerize on oligonucleotides of at least 40–50 bp in length, the minimal length required for signal transduction. To establish th...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2761030/ https://ncbi.nlm.nih.gov/pubmed/18420935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1155406 |
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