Physiological Properties of hERG 1a/1b Heteromeric Currents and a hERG 1b-specific Mutation Associated with Long QT Syndrome

Cardiac I(Kr) is a critical repolarizing current in the heart and a target for inherited and acquired long QT syndrome (LQTS). Biochemical and functional studies have demonstrated that I(Kr) channels are heteromers composed of both hERG 1a and 1b subunits, yet our current understanding of I(Kr) func...

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Main Authors: Sale, Harinath, Wang, Jinling, O'Hara, Thomas J., Tester, David J., Phartiyal, Pallavi, He, Jia-Qiang, Rudy, Yoram, Ackerman, Michael J., Robertson, Gail A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761010/
https://ncbi.nlm.nih.gov/pubmed/18776039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.185249
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