A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD(+ )biosynthetic gene BNA2 in chromosome end protection

BACKGROUND: Telomeres prevent the ends of eukaryotic chromosomes from being recognized as damaged DNA and protect against cancer and ageing. When telomere structure is perturbed, a co-ordinated series of events promote arrest of the cell cycle so that cells carrying damaged telomeres do not divide....

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Hlavní autoři: Greenall, Amanda, Lei, Guiyuan, Swan, Daniel C, James, Katherine, Wang, Liming, Peters, Heiko, Wipat, Anil, Wilkinson, Darren J, Lydall, David
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760873/
https://ncbi.nlm.nih.gov/pubmed/18828915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2008-9-10-r146
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