Molecular Recognition in the P2Y(14) Nucleotide Receptor: Probing the Structurally Permissive Terminal Sugar Moiety of Uridine-5′-diphosphoglucose

The P2Y(14) receptor, a nucleotide signaling protein, is activated by uridine-5′-diphosphoglucose 1 and other uracil nucleotides. We have determined that the glucose moiety of 1 is the most structurally permissive region for designing analogues of this P2Y(14) agonist. For example, the carboxylate g...

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Autori principali: Ko, Hyojin, Das, Arijit, Carter, Rhonda L., Fricks, Ingrid P., Zhou, Yixing, Ivanov, Andrei A., Melman, Artem, Joshi, Bhalchandra V., Kováč, Pavol, Hajduch, Jan, Kirk, Kenneth L., Harden, T. Kendall, Jacobson, Kenneth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760346/
https://ncbi.nlm.nih.gov/pubmed/19502066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.05.024
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