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Enhanced Potency of Nucleotide–Dendrimer Conjugates as Agonists of the P2Y(14) Receptor: Multivalent Effect in G Protein-Coupled Receptor Recognition

The P2Y(14) receptor is a G protein-coupled receptor activated by uridine-5′-diphosphoglucose and other nucleotide sugars that modulates immune function. Covalent conjugation of P2Y(14) receptor agonists to PAMAM (polyamidoamine) dendrimers enhanced pharmacological activity. Uridine-5′-diphosphogluc...

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Autors principals: Das, Arijit, Zhou, Yixing, Ivanov, Andrei A., Carter, Rhonda L., Harden, T. Kendall, Jacobson, Kenneth A.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3106419/
https://ncbi.nlm.nih.gov/pubmed/19572637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc900206g
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