Enhanced Potency of Nucleotide–Dendrimer Conjugates as Agonists of the P2Y(14) Receptor: Multivalent Effect in G Protein-Coupled Receptor Recognition

The P2Y(14) receptor is a G protein-coupled receptor activated by uridine-5′-diphosphoglucose and other nucleotide sugars that modulates immune function. Covalent conjugation of P2Y(14) receptor agonists to PAMAM (polyamidoamine) dendrimers enhanced pharmacological activity. Uridine-5′-diphosphogluc...

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Hlavní autoři: Das, Arijit, Zhou, Yixing, Ivanov, Andrei A., Carter, Rhonda L., Harden, T. Kendall, Jacobson, Kenneth A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3106419/
https://ncbi.nlm.nih.gov/pubmed/19572637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc900206g
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