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Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration

Rac activation by integrins is essential for cell spreading, migration, growth and survival. Based mainly on over-expression of dominant negative mutants, RhoG was proposed to mediate integrin-dependent Rac activation upstream of ELMO and Dock 180. RhoG knockout mice, however, display no significant...

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Detalhes bibliográficos
Main Authors: Meller, Julia, Vidali, Luis, Schwartz, Martin Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759683/
https://ncbi.nlm.nih.gov/pubmed/18505794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.025130
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