Suppression of RhoG activity is mediated by a syndecan 4–synectin–RhoGDI1 complex and is reversed by PKCα in a Rac1 activation pathway

Fibroblast growth factor 2 (FGF2) is a major regulator of developmental, pathological, and therapeutic angiogenesis. Its activity is partially mediated by binding to syndecan 4 (S4), a proteoglycan receptor. Angiogenesis requires polarized activation of the small guanosine triphosphatase Rac1, which...

Full description

Saved in:
Bibliographic Details
Main Authors: Elfenbein, Arye, Rhodes, John M., Meller, Julia, Schwartz, Martin A., Matsuda, Michiyuki, Simons, Michael
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2009
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712988/
https://ncbi.nlm.nih.gov/pubmed/19581409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200810179
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items