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Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration
Rac activation by integrins is essential for cell spreading, migration, growth and survival. Based mainly on over-expression of dominant negative mutants, RhoG was proposed to mediate integrin-dependent Rac activation upstream of ELMO and Dock 180. RhoG knockout mice, however, display no significant...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2759683/ https://ncbi.nlm.nih.gov/pubmed/18505794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.025130 |
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