A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40(phox) and selective defects in neutrophil NADPH oxidase activity

Chronic granulomatous disease (CGD), an immunodeficiency with recurrent pyogenic infections and granulomatous inflammation, results from loss of phagocyte superoxide production by recessive mutations in any 1 of 4 genes encoding subunits of the phagocyte NADPH oxidase. These include gp91(phox) and p...

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Détails bibliographiques
Auteurs principaux: Matute, Juan D., Arias, Andres A., Wright, Nicola A. M., Wrobel, Iwona, Waterhouse, Christopher C. M., Li, Xing Jun, Marchal, Christophe C., Stull, Natalie D., Lewis, David B., Steele, MacGregor, Kellner, James D., Yu, Weiming, Meroueh, Samy O., Nauseef, William M., Dinauer, Mary C.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2009
Sujets:
Phagocytes, Granulocytes, and Myelopoiesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759653/
https://ncbi.nlm.nih.gov/pubmed/19692703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-231498
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